IMI Foundations, Discovery, Epidemiology, and Plasmids

Explain what IMI carbapenemases are, including their Ambler class, catalytic biology, naming, and significance in Enterobacter.

Trace the discovery of IMI-1 and later IMI variants by organism, location, date, source, and genomic context, and relate them to NMC-A.

Analyze the distribution of IMI-producing Enterobacter across species, sequence types, geographic regions, clinical sources, and environmental reservoirs.

Evaluate published evidence linking blaIMI to Enterobacter sequence type 250, including species assignment, IMI allele, source, geographic context, and clonal relatedness.

Compare reported plasmid replicon types and genomic backbones carrying blaIMI-2 and other blaIMI alleles, and assess their documented links to ST250 Enterobacter asburiae outbreaks or other Enterobacter lineages.